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NNMT inhibition may actually improve the adipocytes capacity to oxidize fat by restoring the NAD+-dependent sirtuin activity and mitochondrial function that fatty acid oxidation requires

A useful overview of that link is in microbiota-immune, which explains how microbes steer immune behavior

[36] [37] [38] A long-term study where vitamin B 12 was supplemented across a period of 10 years, led to lower levels of weight gain in overweight or obese individuals (p 20% of elderly individuals showed evidence of marginal vitamin B 12 depletion (serum vitamin B 12 : 148221 pmol/L)

So, if your protocol requires a 250 mcg dose, you would calculate: 250 mcg / 50 mcg/unit = 5 units